Instantaneous Conversion of [11C]CO2 to [11C]CO via Fluoride‐Activated Disilane Species
نویسندگان
چکیده
The development of a fast and novel methodology to generate carbon-11 carbon monoxide ([11 C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11 C]CO2 ) mediated by a fluoride-activated disilane species is described. This methodology allows up to 74 % conversion of [11 C]CO2 to [11 C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl-11 C]N-benzylbenzamide was successfully synthesized from produced [11 C]CO in up to 74 % radiochemical yield (RCY) and >99 % radiochemical purity (RCP) in ≤10 min from end of [11 C]CO2 delivery.
منابع مشابه
Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc00319f Click here for additional data file.
The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemica...
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